View abstract. Forskolin, which was detected only quite recently as a promising drug because of its activity towards adenylate cyclase, is used as a research tool for studying the function of this enzyme. Ishikawa, Y. Isoform-targeted regulation of cardiac adenylyl cyclase. It belongs to Lamiaceae family. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Yokotani K, Chiba T, Sato Y, et al. These flowers are mostly blue or lilac-blue and grow in terminal spikelike racemes or panicles. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Rosmarinic acid is found not only in the plant, but is also produced in undifferentiated cell cultures which even have a much higher content. Description. J Cardiovasc.Pharmacol 2003;41 Suppl 1:S1-S4. Arzneimittelforschung 1981;31:1248-50. 2001;71(6):1931-1938. Stop using coleus at least 2 weeks before a scheduled surgery. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. View abstract. Seamon KB, Daly JW. View abstract. Sashidhara, K. V., Rosaiah, J. N., Kumar, A., Bid, H. K., Konwar, R., and Chattopadhyay, N. Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro. J Urol 1997;158(5):1752-1758. Abstract . A comparative study with dobutamine and sodium nitroprusside. View abstract. Moreover, forskolin has been studied as a bronchodilator in asthmatics and for lowering intraocular pressure, thus treating glaucoma. J Cardiovasc Pharmacol 1990;16:93-100. Hypertension 1998;31(3):872-877. The compound is able to lower hypertension by decreasing the peripheral resistance, and it also has a positive inotropic effect on the heart muscle. Solenostemon scutellarioides is the long Latin name for the species we know as Coleus. Christenson, J. T., Thulesius, O., and Nazzal, M. Impregnation of polytetrafluoethylene (PTFE) vascular grafts with C-14-forskolin, a new concept in surface treatment of grafts. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial. 1995;11(3):173-176. View abstract. View abstract. Medicinal use was mapped to the Paton et al. Acute effects of topical forskolin on aqueous humor dynamics in man. This cultivar grows to a height of 12 inches and is relatively smaller in size compared to the rest of the Coleus plants. Seed and seed rate (2004) phylogenetic analysis. View abstract. View abstract. Shen, Y. H. and Xu, Y. L. Two new diterpenoids from Coleus forskohlii. Some people breathe in (inhale) coleus powder for asthma. Unfortunately, despite the interesting pharmacological activities and the low toxicity of RA, the pure compound is not used for medicinal purposes and therefore a market for rosmarinic acid does not exist. J Asian Nat Prod Res 2006;8(4):355-360. Planta Med 1996;62(2):169-172. View abstract. The synthesis of forskolin seems to be coupled to some state of differentiation; however, this correlation is not as strict as in other systems, where absolutely no secondary compounds are formed in undifferentiated cells. 2013;17(8):1117-22. Calcium channel blockers are a type of medicine used to decrease blood pressure. Nevertheless, numerous publications on this species use the name C. blumei, namely, reports on the production of rosmarinic acid by this species. If the production of forskolin by cell or organ cultures could be further optimized, these in vitro cultures might become a further source for forskolin besides field-grown plants. This work suggested that 70% of medicinal Plectranthus species belonged to the Coleus Clade and that medicinal usage tended to be concentrated in particular clades across the phylogeny. As a result, attempts at a large-scale production of RA were not continued. See Additional Information. Dubey, M. P., Srimal, R. C., Nityanand, S., and Dhawan, B. N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. Therefore, forskolin is used to study the role of adenylate cyclase and cyclic AMP in eukaryotic systems all over the world. Someday, a shortened version, like "soleno" might become a consumer-friendly marketing name for these beauties. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. ... if rather terse, guide to the traditional medicinal uses of the plants of the region, 1346. They have square stems, opposite, toothed, stalked, or stalkless leaves and asymmetrical flowers. Coleus is a plant that has been used since ancient times to treat heart disorders such as high blood pressure and chest pain (angina), as well as respiratory disorders such as asthma. View abstract. The demand for forskolin was mainly satisfied by large-scale and indiscriminate collections of C. forskohlii from wild habitats. Planta Med 1985;6:473-7. Basic Res Cardiol 1989;84 Suppl 1:197-212. Technical production of RA in cell cultures of C. blumei could be economically feasible. Phytother Res 2007;21(11):1105-1108. The first plant was brought to Europe from Java in 1851 and the species became very popular as an ornamental plant (Gardener 1855). Coleus might decrease blood pressure. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. View abstract. It has an aroma similar to camphor and it’s extremely fragrant due to large amount of essential oils present in the plant. Coleus increases blood flow. Other varieties are reproduced by seeds. Medicinal Coleus (Coleus forskohlii . Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. Anesthesiology 2003;99(1):18-26. View abstract. Briq. View abstract. 2010;38(2):661-8. Undem, B. J. and Buckner, C. K. Effects of forskolin alone and in combination with isoproterenol on antigen-induced histamine release from guinea-pig minced lung. Ann Thorac.Surg. Since only eight enzymes are involved in the biosynthetic pathway, all of which are known now, this system is very suitable to study the regulation of this pathway. However, there can be some side effects. View abstract. In an induction medium which promotes differentiation in direction of root formation, root-like structures are formed and forskolin accumulation can be observed. 2016 Apr;32(3):178-83. Coleus amboinicus Lour. Forskolin has a number of promising pharmacological effects and has become an important research tool since its discovery. 1998;93 Suppl 1:66-75. Coleus might decrease blood pressure. J Cyclic Nucleotide Res 1981;7:201-24. It is a perennial aromatic plant with a height of 40-60 cm. View abstract. Christenson JT, Thulesius O, Nazzal MM. It grows in a tropical climate. The blooms have a five-toothed calyx and tubular, two-lipped corolla. The genus Coleus was first described by de Loureiro in 1790. View abstract. View abstract. Preparations from several Coleus species are used in Ayurvedic medicine in India, e.g., preparations from C. amboinicus are active against skin problems and worms. The only style has two stigmas. Thromb Haemost 1989;61:106-10. Asia Pac J Clin Nutr 2006;15(2):267-274. Crop thrives best in areas receiving 70 cm annual rainfall. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Lancet 7-21-1984;2(8395):167. Nebbioso M, Rusciano D, Pucci B, et al. Some calcium channel blockers include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others. 1990;34(4):428-435. Clinical efficacy of Coleus forskohlii (Willd.) View abstract. 2005;13(8):1335-43. Use coleus with caution if you have a heart problem. Lebedinsky, Y., Nordstrom, S. T., Aschoff, S. E., Kapples, J. F., O'Malley, G. J., Kosley, R. W., Jr., Fielding, S., and Hubbard, J. W. Cardiotonic and coronary vasodilator responses to milrinone, forskolin, and analog P87-7692 in the anesthetized dog. J Pharm Pharmacol. Arch Int Pharmacodyn.Ther. Rembold, C. M. and Chen, X. L. Mechanisms responsible for forskolin-induced relaxation of rat tail artery. Breast-feeding: There is not enough reliable information about the safety of taking coleus if you are breast-feeding. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. J Ethnopharmacol 1981;3(1):1-13. 1996;103(12):1463-1467. Coleus blumei is not used for medicinal purposes but there is In 1896, Siebert and Voss placed C. blumei, C. scutellarioides, C. atropurpureus, C. bicolor, C. verschaffelti, and C. hybridus as subspecies into the species C. scutellarioides. The stalks of the stamens are united at their bases into a tube encircling the style. It has been used for over 3,000 years in Ayurvedic Medicine. Kaik, G. and Witte, P. U. View abstract. There is some concern that coleus might interfere with treatment for heart or blood vessel diseases and could make these conditions worse. The tuberous roots contain a labdane diterpene which was called coleonol by one group and forskolin by the other. J Ocul Pharmacol Ther. Coleus carnosus Hassk. View abstract. This could show us how to manipulate these cultures in a direction where secondary compound production starts. A high amount of rosmarinic acid is accumulated in only a few days at the end of the growth phase of the cell cultures. J Urol 1996;155(5):1789-1794. Ammon HP, Muller AB. J Asian Nat Prod Res 2005;7(6):811-815. Battochio, A. P., Sartori, M. S., and Coelho, C. A. Water-soluble extract of Coleus barbatus modulates weight gain, energy utilization and lipid metabolism in secondary biliary cirrhosis: an experimental study in young rats. View abstract. When taken by mouth, coleus is used to treat allergies , dry eye, skin conditions such as eczema and psoriasis , obesity , painful menstrual periods, irritable bowel syndrome ( IBS ), urinary tract infections ( UTI ), bladder infections, advanced cancer , blood clots , sexual problems in men, trouble sleeping ( insomnia ), and convulsions . Wien Med Wochenschr 12-31-1986;136(23-24):637-641. The production of forskolin by in vitro cultures is under investigation only for some years now and further optimization of the culture systems might lead to higher contents of forskolin. With easy manipulations of the culture medium, the biosynthesis of RA can be stimulated. J Int Med Res. View abstract. View abstract. Nebbioso M, Belcaro G, Librando A, et al. Marone, G., Columbo, M., Triggiani, M., Cirillo, R., Genovese, A., and Formisano, S. Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. 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